In the first two seasons, Berg, a slacker, works at a Boston pizza parlor, Beacon Street Pizza, with Pete.
They both attend Tufts University, with Sharon, who after graduation, works as the spokesperson (or apologist) for Immaculate Chemicals.
Berg eventually decides to attend medical school and become a doctor, while Pete drops out of architecture classes to become a career counselor.
The second season also introduces Johnny Donnelly (Nathan Fillion), a jukebox repairman who starts dating Sharon, and Ashley Walker (Suzanne Cryer), a medical school classmate of Berg's who competes with him to be top of the class.
Focusing on the lives of twenty-somethings Michael Bergen, Pete Dunville, and Sharon Carter, the show was originally based on the life of its creator.
The fictional "Beacon Street Pizza" was based on a real pizza restaurant named Theo's Pizza in Teele Square, Somerville, Massachusetts, where show creator Kenny Schwartz worked while attending nearby Tufts University.
The series stars Ryan Reynolds as Michael Leslie "Berg" Bergen, Richard Ruccolo as Peter "Pete" Dunville and Traylor Howard, as campus beauty Sharon Carter (later Carter-Donnelly).The story of season 1 centers around the pizza place.Actors such as Jennifer Westfeldt (Melissa), and Julius Carry (Bill) were credited as secondary cast members to principals Ryan Reynolds, Richard Ruccolo, and Traylor Howard. Bauer, played by David Ogden Stiers, frequently appeared around the pizza place, telling stories of life events which actually occurred in movies.The series premiered on March 10, 1998, as Two Guys, a Girl and a Pizza Place.The episode entitled "The Pilot" was watched by almost 18 million viewers.
At the start of season three, the pizza place is abandoned entirely (hence the change in the show's title), and Berg begins his medical residency.