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This is triggered by the pituitary gland, which secretes a surge of hormonal agents into the blood stream, initiating a chain reaction to occur.The male and female gonads are subsequently activated, which puts them into a state of rapid growth and development; the triggered gonads now commence the mass production of the necessary chemicals.The end of adolescence and the beginning of adulthood varies by country and by function.

During their peak height velocity (the time of most rapid growth), adolescents grow at a growth rate nearly identical to that of a toddler—about 4 inches (10.3 cm) a year for males and 3.5 inches (9 cm) for females.

Some boys may develop gynecomastia due to an imbalance of sex hormones, tissue responsiveness or obesity.

As with most human biological processes, this specific order may vary among some individuals.

Physical growth (particularly in males), and cognitive development can extend into the early twenties.

Thus age provides only a rough marker of adolescence, and scholars have found it difficult to agree upon a precise definition of adolescence.

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